Farnesyltransferase Inhibitors in Cancer Therapy 87 Michel -- Part III

Michel -- Part III

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Farnesyltransferase Inhibitors in Cancer Therapy 87 Michel -- Part IIICutting edge researchers describe their efforts to design, synthesize, and evaluate the biological activities of farensyltransferase inhibitors (FTIs); geranylgeranyltransferase inhibitors (GGTIs) are also discussed as potential anticancer drugs. The authors survey in detail such inhibitors as CAAX box peptidomimetics, FPP mimics, and bisubstrate transition state analogs, and critically review their uses in combination with radiation and other